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We report a case of primary diffuse meningeal melanomatosis, a rare variant of primary malignant melanoma of the CNS, in a 68-year-old woman. The disease mimicked intracranial hypotension syndrome and was diagnosed only at autopsy (CSF cyto logic results were negative). CT revealed hydrocephalus with effacement of the cerebral convexity sulci and abnormal contrast enhancement in the right sylvian and frontoparietal fissures, whereas MR imaging showed diffuse marked dural and leptomeningeal contrast enhancement. In retrospect, these nonspecific findings correlated with the extensive leptomeningeal invasion in the cerebral hemispheres, brain stem and spinal cord. The clinical, radiologic, and pathologic features of diffuse meningeal melanom atosis are reviewed. |
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CAT scan,abnormal
CAT scan,contrast enhanced
cerebrospinal fluid,cytology
cerebrospinal fluid,cytology,false negative
hydrocephalus
melanoma,malignant
melanomatosis,primary malignant
meningeal enhancement
meningitis,carcinomatous
MRI,abnormal
MRI,contrast enhanced
neuropathology
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